Helio is currently competing in the North American IndyCar Series. In IndyCar competition, Castroneves has 14 wins and 28 poles, and has never placed lower than sixth in the standings in a complete season of racing. Prior to IndyCar, Castroneves competed in the CART championship with a highest championship points finish of fourth.

Castroneves won the Indianapolis 500 in 2001, 2002 and 2009, making him one of only nine drivers to date to have won at least three. He finished second to teammate and countryman Gil de Ferran in 2003. Castroneves has won four pole positions for the Indy 500, including back-to-back poles in 2009 and 2010 for the first time since Scott Brayton.